Dr. Sunil Kumar Tripathi is a Bioinformatician and his area of research interest includes Computational Medicinal Chemistry, Computational Biophysics and Molecular Modeling & Drug Design. Dr. Sunil Kumar Tripathi obtained his Ph.D. in Bioinformatics (2014) from the Department of Bioinformatics, Alagappa University, India. He Did his postdoctoral research in International esteemed institute and university that include Regional Center for Biotechnology, Faridabad, India, University of Duisburg Essen, Essen, Germany, University of Michigan, Ann Arbor, USA. His research focuses on molecular modeling techniques to investigate biomolecular systems with emphasis on conformational changes, protein-protein and protein-ligand interactions. He employs Cosolvent Mixed-solvent molecular dynamics (MixMD), classical MD simulations, enhanced sampling, free energy calculations and structure- and ligand-based drug design approaches for the design of small molecules as inhibitors of therapeutically important drug targets.
Currently, he is working as senior researcher in Department of Chemistry, Georgia State University, Atlanta, USA. His work is to understand eukaryotic transcription initiation which begins with the gathering of the transcription preinitiation complex (PIC) onto promoter DNA with the help of transcription factor IID (TFIID), RNA polymerase II (Pol II) and the role of co-activator Mediator utilizing cryo-electron microscopy data, advanced computational modeling, and using emerging powerful tools of computational biology.